Trisodium Citrate Antimicrobial Efficacy at Different Concentrations (4.0%, 30.0%, and 46.7%) in Tunneled Hemodialysis Catheters: An In Vitro Study
Gram-positive bacteria resisted CLS more than Gram-negative bacteria and fungi. 30.0% TSC showed the highest antimicrobial activity across all tested microorganisms. 30.0% and 46.7% TSC were more effective against Candida albicans than heparin. CLS was more effective in silicone catheters than polyurethane catheters. Antimicrobial effectiveness of TSC concentrations may be microbe dependent.Highlights
Effect of catheter lock solution (CLS) on C. albicans growth on silicone and polyurethane catheters (log-transformed average organism count reduction from tryptic soy broth [TSB] control).
Effect of catheter lock solution (CLS) on methicillin-resistant S. aureus (MRSA) growth on silicone and polyurethane catheters (log-transformed average organism count reduction from tryptic soy broth [TSB] control).
Effect of catheter lock solution (CLS) on E. coli growth on silicone and polyurethane catheters (log-transformed average organism count reduction from tryptic soy broth [TSB] control).
Effect of catheter lock solution (CLS) on S. aureus growth on silicone and polyurethane catheters (log-transformed average organism count reduction from tryptic soy broth [TSB] control).
Effect of catheter lock solution (CLS) on S. epidermidis growth on silicone and polyurethane catheters (log-transformed average organism count reduction from tryptic soy broth [TSB] control).
Effect of catheter lock solution (CLS) on P. aeruginosa growth on silicone and polyurethane catheters (log-transformed average organism count reduction from tryptic soy broth [TSB] control).
Effect of catheter lock solution (CLS) on E. faecalis growth on silicone and polyurethane catheters (log-transformed average organism count reduction from tryptic soy broth [TSB] control).
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